4.5 Article

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells

Bonnie Huang et al.

Summary: In this study, the researchers used a CRISPR screen to identify the role of HIF-1 alpha in regulating Tfh cell development. They also discovered multiple components and mechanisms involved in the regulation of Tfh and Th1 cell differentiation.

NATURE COMMUNICATIONS (2022)

Review Biotechnology & Applied Microbiology

PI3K inhibitors are finally coming of age

Bart Vanhaesebroeck et al.

Summary: Overactive PI3K is a frequently activated pathway in cancer, but therapeutic PI3K pathway inhibitors face challenges such as poor drug tolerance and resistance. Several targeted PI3K inhibitors have received regulatory approval, and their potential in cancer immunotherapy has been highlighted.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Immunology

PI3K in T Cell Adhesion and Trafficking

Kristoffer H. Johansen et al.

Summary: PI3K signaling is crucial for T cell activation, differentiation, and trafficking, with PI3K delta being the dominant isoform in T cells. It regulates T cell functions by controlling adhesion receptors and their interaction with antigen-presenting cells. Understanding the role of PI3K delta in T cell migration and localization is important for potential impacts of PI3K delta inhibitors on T cell redistribution and function.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers

Erin Janssen et al.

JCI INSIGHT (2020)

Review Immunology

The multifaceted functions of follicular regulatory T cells

Peter T. Sage et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

Article Biochemical Research Methods

Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute

Binbin Wang et al.

NATURE PROTOCOLS (2019)

Article Biochemical Research Methods

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

Weizhe Li et al.

NATURE PROTOCOLS (2019)

Article Biochemistry & Molecular Biology

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

Alex L. Mitchell et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

James D. Phelan et al.

NATURE (2018)

Article Immunology

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection

Irina Zaretsky et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion

Felix J. Eppler et al.

PLOS ONE (2017)

Article Biotechnology & Applied Microbiology

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench et al.

NATURE BIOTECHNOLOGY (2016)

Review Immunology

PI3Kδ and primary immunodeficiencies

Carrie L. Lucas et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Medicine, Research & Experimental

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

Lucia Stefanini et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis

Sayaka Ishihara et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

Randall J. Platt et al.

Article Multidisciplinary Sciences

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

Jun Yang et al.

NATURE COMMUNICATIONS (2014)

Article Biotechnology & Applied Microbiology

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Wei Li et al.

GENOME BIOLOGY (2014)

Review Immunology

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

Klaus Okkenhaug

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Biochemistry & Molecular Biology

A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes

Peter Reichardt et al.

EMBO JOURNAL (2013)

Review Cell Biology

Talins and kindlins: partners in integrin-mediated adhesion

David A. Calderwood et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Review Immunology

T cell receptor signalling networks: branched, diversified and bounded

Rebecca J. Brownlie et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Immunology

Induction and molecular signature of pathogenic TH17 cells

Youjin Lee et al.

NATURE IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

Ho-Sup Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

Mathieu Gigoux et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Multidisciplinary Sciences

The Tail of Integrins, Talin, and Kindlins

Markus Moser et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

SAP-controlled T-B cell interactions underlie germinal centre formation

Hai Qi et al.

NATURE (2008)

Editorial Material Immunology

The Immunological Genome Project: networks of gene expression in immune cells

Tracy S. P. Heng et al.

NATURE IMMUNOLOGY (2008)

Article Immunology

Rapid default transition of CD4 T cell effectors to functional memory cells

K. Kai McKinstry et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Biochemical Research Methods

A novel flow-cytometry-based assay for quantification of affinity and avidity changes of integrins

MH Konstandin et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2006)

Article Immunology

Importance of integrin LFA-1 deactivation for the generation of immune responses

M Semmrich et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Multidisciplinary Sciences

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

TG Bivona et al.

NATURE (2003)

Review Immunology

PI3K in lymphocyte development, differentiation and activation

K Okkenhaug et al.

NATURE REVIEWS IMMUNOLOGY (2003)

Review Biochemistry & Molecular Biology

Integrins: Bidirectional, allosteric signaling machines

RO Hynes

Article Biochemistry & Molecular Biology

Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

K Katagiri et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)