A specific circuit in the midbrain detects stress and induces restorative sleep

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how stress promotes sleep is unclear. Activity-dependent tagging revealed a subset of ventral tegmental area gamma-aminobutyric acid (GABA)-somatostatin (VTA(Vgat-Sst)) cells that sense stress and drive non-rapid eye movement (NREM) and REM sleep through the lateral hypothalamus and also inhibit corticotropin-releasing factor (CRF) release in the paraventricular hypothalamus. Transient stress enhances the activity of VTA(Vgat-Sst) cells for several hours, allowing them to exert their sleep effects persistently. Lesioning of VTA(Vgat-Sst) cells abolished SDS-induced sleep; without it, anxiety and corticosterone concentrations remained increased after stress. Thus, a specific circuit allows animals to restore mental and body functions by sleeping, potentially providing a refined route for treating anxiety disorders.

Automated summary

Social defeat stress induces sleep in mice, and a subset of VTA(Vgat-Sst) cells plays a crucial role in promoting and maintaining sleep through a specific neural circuit, while also inhibiting CRF release after stress.