期刊
SCHIZOPHRENIA BULLETIN
卷 48, 期 6, 页码 1206-1216出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbac098
关键词
Schizophrenia; Inflammation; Cerebrospinal fluid; Blood-brain barrier
类别
资金
- Independent Research Fund Denmark [7025-00078B]
- Lundbeck Foundation [R268-2016-3925]
- Psykiatrisk Forskningsfond af 1967
Neuroinflammation and blood-brain barrier dysfunction are commonly observed in patients with psychotic disorders. This study found that patients with psychotic disorders had increased blood-brain barrier permeability, higher levels of white blood cells in cerebrospinal fluid, and increased peripheral inflammation in inpatients.
Background and Hypothesis Neuroinflammation and blood-brain barrier (BBB) dysfunction have been observed in patients with psychotic disorders. However, previous studies have mainly focused on selected patients and broad screenings of cerebrospinal fluid (CSF) of patients with recent onset psychosis compared to healthy controls are lacking. Study Design We included 104 patients with recent onset psychotic disorder and 104 individually matched healthy controls. CSF and blood were analyzed for readily available markers assessing neuroinflammation and BBB dysfunction. Primary outcomes were CSF white blood cell count (WBC), total protein, IgG Index, and CSF/serum albumin ratio. Secondary outcomes included additional markers of inflammation and BBB, and analyses of association with clinical variables. Study Results CSF/serum albumin ratio (Relative Mean Difference (MD): 1.11; 95%CI: 1.00-1.23; P = .044) and CSF/serum IgG ratio (MD: 1.17; 95%CI: 1.01-1.36; P = .036) was increased in patients compared to controls. A higher number of patients than controls had CSF WBC >3 cells/mu l (seven vs. one, OR: 7.73, 95%CI: 1.33-146.49, P = .020), while WBC>5 cells/mu l was found in two patients (1.9%) and no controls. Inpatients had higher serum WBC and neutrophil/lymphocyte ratio (all p-values for effect heterogeneity < .011). Mean CSF WBC (MD: 1.10; 95%CI: 0.97-1.26), protein (MD: 1.06; 95%CI: 0.98-1.15) and IgG index (MD: 1.05; 95%CI: 0.96-1.15) were not significantly elevated. Conclusions When comparing a broad group of patients with psychotic disorders with healthy controls, patients had increased BBB permeability, more patients had high CSF WBC levels, and inpatients had increased peripheral inflammation, consistent with the hypothesis of a subgroup of patients with increased activation of the immune system.
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