Synthesis of Isatin-Based Oxo-Spiro Chromene Schiff's Bases as Antibacterial and Anticancer Agents

Herein, we report series of isatin-based oxo-spiro chromene Schiff's bases, synthesized by condensing 2,7-diamino-2'-oxospiro[chromene-4,3'-indoline]-3-carbonitrile with aromatic aldehydes using efficient acid catalyst, silica sulfuric acid (SSA). Spectroscopic techniques have corroborated the formation of desired products. Derivatives were screened in vitro for antibacterial and anticancer activities. Molecular docking was also performed to predict the possible mode of action of these derivatives.

Automated summary

In this study, a series of isatin-based oxo-spiro chromene Schiff's bases were synthesized by condensing 2,7-diamino-2'-oxospiro[chromene-4,3'-indoline]-3-carbonitrile with aromatic aldehydes using silica sulfuric acid (SSA) as an efficient acid catalyst. Spectroscopic techniques confirmed the formation of the desired products, which were then screened in vitro for antibacterial and anticancer activities. Molecular docking was also conducted to predict the potential mode of action of these derivatives.