期刊
RHEUMATOLOGY
卷 62, 期 -, 页码 SI12-SI19出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keac421
关键词
SSc; fibrosis; inflammation; toll-like receptors; cytokines; LPS; DAMPs
类别
SSc is an autoimmune disease characterized by vascular abnormalities, inflammation, and fibrosis of the skin and lungs. Inflammation and fibrosis are closely connected in this disease, and Toll-like receptors play a significant role in its pathogenesis and may be a potential target for therapeutic intervention.
SSc is an autoimmune disease that has features of vascular abnormalities, inflammation and skin and lung fibrosis. Toll-like receptors (TLRs) are sentinel receptors that serve to recognize pathogens or internal danger signals leading to downstream signalling pathways that ultimately lead to inflammation and modification of adaptive immunity. Inflammation and fibrosis appear intricately connected in this disease and TLR ligation on fibroblasts can directly activate these cells to produce copious amounts of collagen, a hallmark of disease. The presence of damage-associated molecular patterns in association with fibrosis has been highlighted. Given their prominent role in disease, this review discusses the evidence of their expression and role in disease pathogenesis and possible therapeutic intervention to mitigate fibrosis.
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