期刊
JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 30, 期 8, 页码 1577-1584出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2016.07.014
关键词
Haptoglobin; Coronary Artery Disease; Diabetes; Epidemiology
资金
- Division of Diabetes Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Disease [U01 DK094176, U01 DK094157]
- National Eye Institute
- National Institute of Neurologic Disorders and Stroke
- General Clinical Research Centers Program
- Clinical Translational Science Center Program, Bethesda, Maryland, USA
- NIH [R01DK085226-03]
- Israel Science Foundation
- Rappaport Institute for Medical Sciences
Aims/hypothesis: Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. We assessed the association of Hp2-2 with incident CAD over 26 years of follow-up in 1303 Caucasian participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Methods: DCCT randomized volunteers with type 1 diabetes to intensive versus conventional therapy within two cohorts: 'primary prevention' with 1-5 years diabetes duration and 'secondary intervention' with 1-15 years diabetes duration and early retinopathy, with or without albuminuria, but no advanced complications. CAD was defined as myocardial infarction (MI) or death judged to be from CAD, silent MI, angina, coronary revascularization, or congestive heart failure due to CAD. Results: In the entire DCCTcohort, Hp2-2 was not significantly associated with incident CAD or MI. However, in pre-specified exploratory subgroup analyses, an increased MI risk was suggested in the secondary cohort for those with Hp2-2. Conclusions/interpretation: The analysis does not statistically confirm an overall association between Hp 2-2 and incident CAD, however, some suggestions of associations were observed in secondary analyses. (C) 2016 Elsevier Inc. All rights reserved.
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