期刊
JOURNAL OF DERMATOLOGY
卷 43, 期 10, 页码 1117-1145出版社
WILEY
DOI: 10.1111/1346-8138.13392
关键词
atopic dermatitis; clinical practice guideline; diagnosis; evidence-based medicine; treatment
类别
资金
- JDA
- Ministry of Health, Labor and Welfare (as a Research Project on Measures for Intractable Diseases [Research on Allergic Disease and Immunology])
- Japan Agency for Medical Research and Development (as a Practical Research Project for Allergic Diseases and Immunology [Research on Allergic Diseases and Immunology])
- Grants-in-Aid for Scientific Research [15K09793] Funding Source: KAKEN
Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. Most patients have an atopic predisposition. The definitive diagnosis of AD requires the presence of all three features: (i) pruritus; (ii) typical morphology and distribution of the eczema; and (iii) chronic and chronically relapsing course. The current strategies to treat AD in Japan from the perspective of evidence-based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice.
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