Gut microbiota is associated with weight gain in children treated with atypical antipsychotic: A pilot longitudinal study

We studied longitudinal changes in the microbiome with weight gain during atypical antipsychotics (APs) treatment. 43 inpatients naive to AP paediatric medication were included in the longitudinal microbiota study. The baseline composition of the gut microbiome in the case group was characterised by an increase in Para-bacteroides and Eubacterium_hallii_group. During the follow-up, the relative abundances of Romboutsia and Klebsiella increased significantly after 3 months of AP treatment; however, no significant changes in these two gut bacteria were observed in the control group. The baseline composition of the gut microbiome contributed to the risk of AP-associated weight gain.

Automated summary

This study investigated the longitudinal changes in the microbiome during treatment with atypical antipsychotics and found that the baseline composition of the gut microbiome was associated with the risk of weight gain associated with antipsychotic medication.