Transient and durable T cell reactivity after COVID-19

Article Immunology

Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood

Andreas Tornell et al.

Summary: A whole-blood stimulation assay was developed to detect SARS-CoV-2-specific T cells in previously infected or vaccinated individuals. The study found that T-cell responses persisted longer than immunoglobulin G responses and could be used to evaluate complications and vaccine-induced T-cell immunity.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Biochemistry & Molecular Biology

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

Yu Gao et al.

Summary: This study found that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against the Omicron variant. Additionally, T cells induced by BNT162b2 vaccination exhibit higher cross-reactivity to the Omicron variant compared to T cells induced by prior SARS-CoV-2 infection.

NATURE MEDICINE (2022)

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Letter Medicine, General & Internal

Protection against the Omicron Variant from Previous SARS-CoV-2 Infection

Heba N. Altarawneh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Cell Biology

Characterization of memory T cell subsets and common γ-chain cytokines in convalescent COVID-19 individuals

Anuradha Rajamanickam et al.

Summary: This study investigated the composition of T cell subsets in convalescent individuals of SARS-CoV2 infection and found alterations in lymphocyte counts, memory T cell subset frequencies, and common gamma-chain cytokines during the recovery process.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Letter Medicine, General & Internal

Severity of SARS-CoV-2 Reinfections as Compared with Primary Infections

Laith J. Abu-Raddad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Immunology

The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy

Jongdae Lee et al.

Summary: Immune checkpoint inhibition has become a key aspect of cancer therapy, with CD4(+) T cells playing a crucial role in modulating immune responses against tumors. Different subsets of helper T cells have varying impacts on the clinical response to immune checkpoint therapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Repositioning TH cell polarization from single cytokines to complex help

Selma Tuzlak et al.

Summary: Three decades ago, the description of helper T cell polarization led to a dramatic growth in the T cell universe, with new subsets emerging. Categorizing T helper cells based on the help they provide offers a better understanding of their complexity and diversity.

NATURE IMMUNOLOGY (2021)

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Review Immunology