4.8 Article

Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconstituted in vitro

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Summary: Lipid droplets, once seen as inert fat drops, are now recognized as vital organelles with key functions in lipid biology and cellular communication. Diseases factors mutated in hereditary disorders have been linked to LD contact site proteins, indicating the importance of LD-organelle contacts in disease development and progression. Additionally, LD contact sites are dynamically rearranged in response to infections and pathological metabolic conditions, suggesting their crucial role in disease pathways.

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