Rapid detection of lamotrigine by a water stable fluorescent lanthanide metal-organic framework sensor

Lamotrigine (LTG) is an antiepileptic drug, but excessive use of LTG can cause life-threatening skin rashes. Herein, a new type of Tb-MOF with two emitting centers for LTG detection was designed and synthesized. The unique crystal structure is derived from a hexacarboxylic acid ligand and lanthanide Tb3+ ion. The application of ratiometric fluorescence sensing improves the accuracy for detecting LTG. The Tb-MOF also displays excellent sensitivity with fast response within 40 s, low detection limit of 1.66 mu M and high recyclability. This research provides important significance for using lanthanide metal-organic framework (Ln-MOF) as the platform for fluorescent sensing.

Automated summary

In this study, a new type of Tb-MOF with two emitting centers was designed and synthesized for detection of lamotrigine (LTG). The ratiometric fluorescence sensing technique was applied to improve the accuracy of LTG detection. The Tb-MOF exhibited excellent sensitivity with fast response and high recyclability. This research demonstrates the significance of using lanthanide metal-organic frameworks (Ln-MOFs) as platforms for fluorescent sensing.