期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 83, 期 3, 页码 167-173出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2016.05.015
关键词
Tumor-associated macrophages; Immunosuppression; M2 polarization; Chemokines; Angiogenetic factors; Regulatory t cells
类别
资金
- Japan Society for the Promotion of Science [25461682]
- Grants-in-Aid for Scientific Research [25461682] Funding Source: KAKEN
Immunosuppressive tumor-associated macrophages (TAMs) promote an immunosuppressive environment in the tumor-bearing host, together with regulatory T cells (Tregs). TAMs compose cancer stroma in skin cancers including melanomas and non-melanomas. The majority of tumor-associated macrophages (TAMs) are alternatively activated M2 macrophages that favor tumor development, and they comprise one of the main populations of inflammatory cells in skin cancers. On the other hand, TAMs could be modulated into M1-type macrophages that suppress tumor growth by stimulating and recruiting Th1 and effector cells in the tumor sites. Therefore, TAMs are a target for immunotherapy in various cancers. In this review, we discuss the definition and suppressive mechanisms of TAMs, as well as their biological activities in tumor-bearing hosts to assess potential therapeutic strategies. (C) 2016 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据