Quality of life impairment after a diagnosis of Cushing's syndrome

This brief review is devoted mainly to publications in the last 5 years dealing with health-related quality of life (QoL) after a diagnosis of endogenous hypercortisolism, due to pituitary-dependent Cushing's disease (CD) or any other cause of Cushing syndrome (CS). Despite improvement after treatment, persistent physical morbidity, neurocognitive problems like worse executive capacity and memory as well as stress intolerance, depressive symptoms and more anxiety, lead to long-term impairment of QoL.

Automated summary

This brief review focuses on recent publications in the last five years that discuss health-related quality of life (QoL) in individuals diagnosed with endogenous hypercortisolism, specifically pituitary-dependent Cushing's disease (CD) or any other cause of Cushing syndrome (CS). Despite improvements from treatment, individuals still experience physical morbidity, neurocognitive problems, and decreased stress tolerance, leading to long-term impairment of QoL.