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Yanfang Cheng et al.
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Franziska E. Marquard et al.
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Hye-Kyung Park et al.
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Juan Feng et al.
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Rui Liu et al.
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NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90
John D. Huck et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Clinical and biological significances of heat shock protein 90 (Hsp90) in human nasopharyngeal carcinoma cells and anti-cancer effects of Hsp90 inhibitor
Fangxian Liu et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study
Xin-Ran Tang et al.
LANCET ONCOLOGY (2018)
Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes
Xiaojie Huang et al.
MEDCHEMCOMM (2018)
3 '-epi-12 beta-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells
Yan Sun et al.
THERANOSTICS (2018)
Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold
Sanket J. Mishra et al.
ACS CHEMICAL BIOLOGY (2017)
Resorcinol-Based Grp94-Selective Inhibitors
Anuj Khandelwal et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
Andrew R. Stothert et al.
SCIENTIFIC REPORTS (2017)
Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1
Xue Meng et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2016)
PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment
Angel Guerrero-Zotano et al.
CANCER AND METASTASIS REVIEWS (2016)
Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold
Vincent M. Crowley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Combining antiangiogenic therapy and radiation in nasopharyngeal carcinoma
Zhuo Chen et al.
SAUDI MEDICAL JOURNAL (2015)
Dual PI3K/mTOR Inhibitors, GSK2126458 and PKI-587, Suppress Tumor Progression and Increase Radiosensitivity in Nasopharyngeal Carcinoma
Tongxin Liu et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Development of radamide analogs as Grp94 inhibitors
Aaron Muth et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models
Brigette B. Y. Ma et al.
CANCER LETTERS (2014)
gWEGA: GPU- Accelerated WEGA for Molecular Superposition and Shape Comparison
Xin Yan et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2014)
Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors
Rohit Bhat et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein-Barr Virus Lytic Replication
Hui Cui et al.
JOURNAL OF NATURAL PRODUCTS (2014)
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
Amy S. Lee
NATURE REVIEWS CANCER (2014)
The Therapeutic Target Hsp90 and Cancer Hallmarks
Yoshihiko Miyata et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Preclinical evaluation of the PI3K-mTOR dual inhibitor PF-04691502 as a novel therapeutic drug in nasopharyngeal carcinoma
Chi Hang Wong et al.
INVESTIGATIONAL NEW DRUGS (2013)
The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways
Dong-Hua Luo et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2013)
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
Pallav D. Patel et al.
NATURE CHEMICAL BIOLOGY (2013)
As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelialmesenchymal transition and activation of AKT signaling
Xin-Jian Li et al.
CARCINOGENESIS (2012)
Development of a Grp94 inhibitor
Adam S. Duerfeldt et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Activation of AKT is associated with metastasis of nasopharyngeal carcinoma
Ying Liu et al.
TUMOR BIOLOGY (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition
Jianguo Zhuang et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)
Targeting the dynamic HSP90 complex in cancer
Jane Trepel et al.
NATURE REVIEWS CANCER (2010)
Overproduction of Cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma: Implication for therapy
Xiao-ming Huang et al.
CANCER LETTERS (2009)
Targeted Inhibition of the EGFR Pathways Enhances Zn-BC-AM PDT-Induced Apoptosis in Well-Differentiated Nasopharyngeal Carcinoma Cells
Ho-Kee Koon et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
Different Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug Design
Robert M. Immormino et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
Timothy A. Yap et al.
CURRENT OPINION IN PHARMACOLOGY (2008)
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman et al.
NATURE REVIEWS GENETICS (2006)