4.7 Article

Sesquiterpene lactone and its unique proaporphine hybrids from Magnolia grandiflora L. and their anti-inflammatory activity

期刊

PHYTOCHEMISTRY
卷 200, 期 -, 页码 -

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113211

关键词

Magnolia grandiflora L.; Magnoliaceae; Sesquiterpene lactone-proaporphine hybrids; Sesquiterpene; Quantum mechanics calculations

资金

  1. Korea Bioactive Natural Material Bank [NRF-2017M3A9B8069409]
  2. Basic Science Research Program through National Research Foundation of Korea (NRF) - Korea government (MSIT) [NRF-2022R1A2C2005061]

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Two undescribed sesquiterpene lactone-proaporphine hybrid skeletons, two undescribed sesquiterpenes, and four known compounds were isolated from the aerial part of Magnolia grandiflora L. The structures of isolated compounds were determined using various methods. These compounds were investigated for their anti-inflammatory activity.
Two undescribed sesquiterpene lactone-proaporphine hybrid skeletons, two undescribed sesquiterpenes, and four known compounds were isolated from the aerial part of Magnolia grandiflora L. The structures of isolated compounds were unambiguously determined based on the interpretation of a combination of NMR spectroscopy, HRESIMS, DP4+ probability calculation of carbon data, X-ray crystallographic analyses, and ECD calculation. The isolated compounds were investigated for their anti-inflammatory activity against nitric oxide production and the protein expression of COX-2 in LPS-stimulated RAW 264.7 cells.

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