Pulsatile Basal Insulin Secretion Is Driven by Glycolytic Oscillations

In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism.

Automated summary

This study investigates a possible mechanism for basal insulin oscillations and demonstrates oscillations in glycolysis using a mathematical model, suggesting it as an alternative mechanism compared to the calcium-dependent mechanism observed at high glucose levels.