Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills

The roles of oxytocin (OT) and arginine-vasopressin (AVP) as crucial modulators of social cognition and related behaviours have been extensively addressed in the literature. The involvement of these neuropeptides in social cognition in ageing, however, and a potential mediating effect of basic cognitive capacities on this link, are not well understood. To fill these research gaps, this study assessed associations of plasma OT and AVP levels with dynamic emotion identification accuracy in generally healthy older men (aged 55-95 years) and probed the underlying roles of crystallized and fluid cognition in these associations. Higher plasma OT levels were associated with lower accuracy in dynamic emotion identification, with this negative relationship fully mediated by cognition. For plasma AVP levels, in contrast, there was no association with dynamic emotion identification accuracy. Integrated within existing theoretical accounts, results from this study advance understanding of the neuropeptide-social cognition link in ageing and support basic cognitive capacities as mediators in this association.This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.

Automated summary

This study investigated the associations between plasma oxytocin and arginine-vasopressin levels and dynamic emotion identification accuracy in older men. The results showed that higher plasma oxytocin levels were associated with lower accuracy, and this relationship was fully mediated by cognition. In contrast, plasma arginine-vasopressin levels did not show any association with dynamic emotion identification accuracy.