期刊
PHARMACOLOGICAL RESEARCH
卷 183, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2022.106391
关键词
Drug; Marine; Sea; Pharmacology; Pharmaceutical; Review; Toxicology; Pipeline; Preclinical
资金
- Midwestern University
- University of Puerto Rico [1SC1GM086271-01A1]
- Regione Campania-POR Campania FESR 2014/2020 Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie- Campania Oncoterapie [B61G18000470007]
The 2018 marine pharmacology literature review continues to provide novel pharmacology and lead compounds for clinical marine pharmaceutical research. The review reports antibacterial, antifungal, antiviral activities of various marine compounds, as well as their effects on diabetes, inflammation, immune system, and nervous system.
The 2018 marine pharmacology literature review represents a continuation of the previous 11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during 2018 was performed by investigators in 44 countries and contributed novel pharmacology for 195 marine compounds. The peer-reviewed marine natural products pharmacology literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and anti-viral activities for 53 compounds, 73 compounds which presented antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 69 compounds were reported to show miscellaneous mechanisms of action which may contribute upon further investigation to several pharmacological classes. Thus, in 2018, the preclinical marine natural product pharmacology pipeline continued to report novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, which currently contributes to therapeutic strategies for several disease categories.
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