期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 475, 期 1, 页码 37-48出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-022-02721-8
关键词
Oxygen; Respiration; Neural excitability; Cognition; Nitric oxide
类别
Oxygen is crucial for neural metabolism, but the brain often has more oxygen than it needs. Changes in respiration rate, tied to the arousal state of the brain and cognition, can dynamically increase oxygen levels. The effects of these oxygenation changes on neural dynamics related to attention and arousal are still uncertain.
Oxygen is critical for neural metabolism, but under most physiological conditions, oxygen levels in the brain are far more than are required. Oxygen levels can be dynamically increased by increases in respiration rate that are tied to the arousal state of the brain and cognition, and not necessarily linked to exertion by the body. Why these changes in respiration occur when oxygen is already adequate has been a long-standing puzzle. In humans, performance on cognitive tasks can be affected by very high or very low oxygen levels, but whether the physiological changes in blood oxygenation produced by respiration have an appreciable effect is an open question. Oxygen has direct effects on potassium channels, increases the degradation rate of nitric oxide, and is rate limiting for the synthesis of some neuromodulators. We discuss whether oxygenation changes due to respiration contribute to neural dynamics associated with attention and arousal.
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