期刊
JOURNAL OF DENTAL RESEARCH
卷 95, 期 6, 页码 605-612出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034516638027
关键词
neuroimaging; limbic system; learning; motivation; d-cycloserine; l-dopa
资金
- National Center for Complementary and Integrative Health [AT007987]
- National Institute of Dental and Craniofacial Research [DE02276]
- National Institute of Neurological Disorders and Stroke [NS035115]
- Canadian Institutes of Health Research
Human neuroimaging studies and complementary animal experiments now identify the gross elements of the brain involved in the chronification of pain. We briefly review these advances in relation to somatic and orofacial persistent pain conditions. First, we emphasize the importance of reverse translational research for understanding chronic pain-that is, the power of deriving hypotheses directly from human brain imaging of clinical conditions that can be invasively and mechanistically studied in animal models. We then review recent findings demonstrating the importance of the emotional brain (i.e., the corticolimbic system) in the modulation of acute pain and in the prediction and amplification of chronic pain, contrasting this evidence with recent findings regarding the role of central sensitization in pain chronification, especially for orofacial pain. We next elaborate on the corticolimbic circuitry and underlying mechanisms that determine the transition to chronic pain. Given this knowledge, we advance a new mechanistic definition of chronic pain and discuss the clinical implications of this new definition as well as novel therapeutic potentials suggested by these advances.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据