期刊
JOURNAL OF DENTAL RESEARCH
卷 95, 期 12, 页码 1341-1349出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034516652383
关键词
ciliary proteins; cellular mechanotransduction; osteoarthritis; osteosarcoma; chondrosarcoma; skeletal development
资金
- National Institute of Dental and Craniofacial Research
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of Aging, part of the National Institutes of Health [DE023105, AR066101, AG048388]
Primary cilia, present on most mammalian cells, function as a sensor to sense the environment change and transduce signaling. Loss of primary cilia causes a group of human pleiotropic syndromes called Ciliopathies. Some of the ciliopathies display skeletal dysplasias, implying the important role of primary cilia in skeletal development and homeostasis. Emerging evidence has shown that loss or malfunction of primary cilia or ciliary proteins in bone and cartilage is associated with developmental and function defects. Intraflagellar transport (IFT) proteins are essential for cilia formation and/or function. In this review, we discuss the role of primary cilia and IFT proteins in the development of bone and cartilage, as well as the differentiation and mechanotransduction of mesenchymal stem cells, osteoblasts, osteocytes, and chondrocytes. We also include the role of primary cilia in tooth development and highlight the current advance of primary cilia and IFT proteins in the pathogenesis of cartilage diseases, including osteoarthritis, osteosarcoma, and chondrosarcoma.
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