Motivational interviewing to support medication adherence in adults with chronic conditions: Systematic review of randomized controlled trials

Objectives: To systematically review published randomized controlled trials (RCTs) assessing the efficacy of MI to support medication adherence in adults with chronic conditions. Methods: A systematic review (PROSPERO-CRD42020025374) was performed by searching in Pubmed/MED-LINE, PsycINFO, The Cochrane Library and Web of Science. Studies were included for the following: RCTs assessing the impact of MI on medication adherence among adults with chronic diseases. Two reviewers con-ducted independent screening of records and full-text articles published until July 2020. Quality was assessed with the Risk of Bias 2 tool for RCTs. Results: From 1262 records identified, 54 RCTs were included. The MI interventions were delivered alone or in combination with other interventions, and varied in mode of delivery (e.g. face-to-face, phone), exposure level (duration, number of sessions), and provider characteristics (profession, training). Most interventions were developed in infectious diseases (n = 16), cardiology (n = 14), psychiatry (n = 8), and endocrinology (n = 7). Medication adherence showed significant improvement in 23 RCTs, and other clinical outcomes were improved in 19 RCTs (e.g. risky behaviors, disease symptoms). Conclusions: MI is an approach to medication adherence support with an increasing evidence base in several clinical domains and further potential for adaptation to different settings. Practice implications: In further studies, particular attention should focus on methodological issues such as the populations of patients to include - patients with suboptimal adherence, the evaluation of fidelity to the MI spirit and components, and a sound measurement of medication adherence and clinical outcomes.

Automated summary

This study systematically reviewed randomized controlled trials (RCTs) to assess the efficacy of Motivational Interviewing (MI) in supporting medication adherence in adults with chronic conditions. The review found that MI had a significant positive impact on medication adherence and other clinical outcomes. MI shows promise as an approach to support medication adherence in different clinical settings.