期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 235, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.prp.2022.153959
关键词
LncRNA; Intervertebral disc degeneration (IDD); Apoptosis; Proliferation; Senescence; Autophagy
类别
资金
- National Natural Science Foundation of China [31960175]
Intervertebral disc degeneration is a crucial pathological process in the development of low back pain, and the changes in the life process of nucleus pulposus cells play a major role. Long noncoding RNAs have emerged as important regulators in IDD, influencing cellular signaling pathways and cellular activities. Understanding lncRNAs can aid in discovering new therapeutic targets and treatment strategies for IDD.
Intervertebral disc degeneration (IDD) is a key pathological process underlying low back pain. Although, to date, specific molecular mechanisms have not been elucidated, at the cellular level, it is mainly due to pathological changes in the life process of nucleus pulposus (NP) cells in the intervertebral disc (IVD). These changes are closely related to cell proliferation, apoptosis, senescence, autophagy, inflammation, and extracellular matrix (ECM) remodeling. Long noncoding RNAs (lncRNAs) have gradually become a focus of scientific research because of their functional complexity and local tissue specific expression. Moreover, they mediate a series of cellular signaling pathways in NP cells by competing for microRNA (miRNA) or directly targeting gene expression by mRNA adsorption, thereby regulating cell life activities that play a vital role in the mechanism underlying IDD. In-depth studies on lncRNAs can help identify new therapeutic targets or aid in developing IDD treatment strategies at the gene level and those based on regenerative medicine, thus providing new ideas for researchers. This article reviews the classification, biological functions, mechanisms of action, and therapeutic potential of lncRNAs in IDD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据