Backward leaning during gait: An underrecognized sign in Niemann-Pick type C

Niemann-Pick type C (NPC) is a rare but treatable lysosomal disorder with heterogeneous clinical presentations including cognitive impairment, movement disorders and vertical gaze palsy. We illustrate five cases of genetically confirmed NPC and highlight backward leaning during gait as a relevant clinical sign and a useful diagnostic clue.

Automated summary

This article presents five genetically confirmed cases of NPC and highlights backward leaning during gait as a useful diagnostic clue.