Systematic review of Plasmodium knowlesi in Indonesia: a risk of emergence in the context of capital relocation to Borneo?

Background The Indonesian Republic plans to relocate its capital from Jakarta to East Kalimantan, Borneo Island, in the next few years. This relocation may be associated with deforestation, decreased biodiversity, and an increased risk of emerging zoonotic infections, including Plasmodium knowlesi malaria. The Malaysian part of Borneo Island is one of the main hotspots of P. knowlesi malaria. Methods Considering this risk, we evaluated the transmission dynamics of P. knowlesi in the Indonesian Archipelago based on a literature search and extensive review of data from the Indonesian Ministry of Health. Results We report that 545 P. knowlesi cases were documented in Indonesia, mainly in the Aceh and North Sumatra provinces, with 95% of these occurring in the last 4 years. Conclusions The main P. knowlesi vectors are present in the area of the future capital, requiring strengthened surveillance to reduce the risk of emerging cases in a rapidly growing population.

Automated summary

The planned capital relocation in Indonesia may increase the risks of deforestation, decreased biodiversity, and the emergence of zoonotic infections like Plasmodium knowlesi malaria. Based on our analysis, the main vectors of P. knowlesi are present in the area of the future capital, emphasizing the need for strengthened surveillance. We reported 545 documented cases of P. knowlesi in Indonesia, mostly occurring in the last 4 years.