期刊
JOURNAL OF DAIRY SCIENCE
卷 99, 期 1, 页码 53-56出版社
ELSEVIER SCIENCE INC
DOI: 10.3168/jds.2015-10005
关键词
acute respiratory distress syndrome (ARDS); camel milk (CM); inflammatory response; oxidative stress; mitogen-activated protein kinase (MAPK) signaling pathway
资金
- Natural Science Foundation of Shandong Province, China [ZR2014HM112, ZR2014HL004, UF201403]
- Science and Technology Development Plan of Shandong Province, China [2011GSF11830]
- Taishan Scholar project of Shandong Province, China
Acute respiratory distress syndrome (ARDS) is a complex syndrome disorder with high mortality rate. Camel milk (CM) contains antiinflammatory and antioxidant properties and protects against numerous diseases. This study aimed to demonstrate the function of CM in lipopolysaccharide (LPS)-induced ARDS in rats. Camel milk reduced the lung wet:dry weight ratio and significantly reduced LPS-induced increases in neutrophil infiltration, interstitial and intra-alveolar edema, thickness of the alveolar wall, and lung injury scores of lung tissues. It also had antiinflammatory and antioxidant effects on LPS-induced ARDS. After LPS stimulation, the levels of proinflammatory cytokines (tumor necrosis factor-alpha, IL-10, and IL-1 beta) in serum and oxidative stress markers (malondialdehyde, myeloperoxidase, and total antioxidant capacity) in lung tissue were notably attenuated by CM. Camel milk also downregulated mitogen-activated protein kinase signaling pathways. Given these results, CM is a potential complementary food for ARDS treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据