☆ 4.3 Article

Epigallocatechin Gallate Relieved PM2.5-Induced Lung Fibrosis by Inhibiting Oxidative Damage and Epithelial-Mesenchymal Transition through AKT/mTOR Pathway

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Environmental Sciences

PM2.5 aggravates airway inflammation in asthmatic mice: activating NF-κB via MyD88 signaling pathway

Lei Wang et al.

Summary: This study observed the effects of PM2.5 on inflammatory response in lung tissue of deficient mice and found that PM2.5 may activate NF-κB through the TLR2/TLR4/MyD88 signaling pathway and exacerbate allergic inflammation in the lungs of asthmatic mice.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2023)

添加到收藏夹

Article Physiology

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

Vincent C. Auyeung et al.

Summary: The study reveals that IRE1 alpha, a central mediator of the unfolded protein response, plays a critical role in promoting the abundance and function of DATPs. Inhibition of IRE1 alpha signaling reduces DATP cell number and fibrosis, indicating the cell-autonomous promotion of transition into the DATP state by IRE1 alpha. Furthermore, IRE1 alpha enhances the profibrotic phenotype of DATPs by regulating integrin alpha v beta 6 expression and DNA damage response signaling. Pharmacological blockade of IRE1 alpha signaling helps resolve the DATP state, ameliorating fibrosis and promoting lung regeneration.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2022)

添加到收藏夹

Article Environmental Sciences

Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China

Di Tian et al.

Summary: The study aimed to identify the factors affecting lung function and the correlation between PM2.5 exposure and lung function in a rural Chinese population. Results showed that factors such as sex, age, cooking oil fumes exposure, and occupational exposure were negatively correlated with lung function, while educational level, economic status, tea consumption, and alcohol consumption were positively correlated. Additionally, long-term exposure to high concentrations of PM2.5 was associated with reduced lung function in rural areas in northwestern China.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Extracellular vesicles derived from PM2.5-exposed alveolar epithelial cells mediate endothelial adhesion and atherosclerosis in ApoE-/- mice

Yongheng Gao et al.

Summary: Extracellular vesicles derived from PM2.5-exposed alveolar epithelial cells play a significant role in the development of atherosclerosis by activating the I kappa B alpha-NF-kappa B-VCAM1 signaling pathway and increasing the adhesion of endothelial cells.

FASEB JOURNAL (2022)

添加到收藏夹

Article Agriculture, Multidisciplinary

Ginsenoside Rg2 Ameliorating CDAHFD-Induced Hepatic Fibrosis by Regulating AKT/mTOR-Mediated Autophagy

Ziwei He et al.

Summary: The study demonstrates that G-Rg2 can improve liver issues induced by a high-fat diet, including its anti-fibrosis effects and impact on the AKT/mTOR signaling pathway.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

添加到收藏夹

Article Environmental Sciences

Air pollution and health impacts during the COVID-19 lockdowns in Grenoble, France

Marie-Laure Aix et al.

Summary: The study compared the changes in air quality during two lockdown periods in 2020 to a reference period from 2015 to 2019, finding that NO2 and PM2.5 had the largest reductions during the lockdowns. The decreases in PM2.5 and NO2 were associated with reduced health risks for various conditions.

ENVIRONMENTAL POLLUTION (2022)

添加到收藏夹

Article Environmental Sciences

PM2.5 induces pulmonary microvascular injury in COPD via METTL16-mediated m6A modification

Xiaolan Guo et al.

Summary: This study established PM2.5-induced COPD rat models and found that PM2.5 induced pulmonary microvascular injury by accelerating vascular endothelial apoptosis, increasing vascular permeability, and reducing angiogenesis, thereby contributing to COPD development. The study further confirmed that METTL16 regulates the expression of Sulf2 through m(6)A modification, playing a role in PM2.5-induced microvascular injury.

ENVIRONMENTAL POLLUTION (2022)

添加到收藏夹

Article Integrative & Complementary Medicine

Folecitin Isolated from Hypericum oblongifolium Exerts Neuroprotection against Lipopolysaccharide-Induced Neuronal Synapse and Memory Dysfunction via p-AKT/Nrf-2/HO-1 Signalling Pathway

Umar Farooq et al.

Summary: The flavonoid folecitin showed significant medicinal potency in alleviating memory impairment induced by lipopolysaccharide-mediated amyloid beta production pathway in mice, possibly by inhibiting expression of apoptotic proteins, regulating synaptic function, and activating endogenous antioxidant proteins.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

添加到收藏夹

Article Neurosciences

Activation of the GPX4/TLR4 Signaling Pathway Participates in the Alleviation of Selenium Yeast on Deltamethrin-Provoked Cerebrum Injury in Quails

Jiayi Li et al.

Summary: This study investigated the therapeutic potential of selenium yeast (SY) on DLM-induced cerebral injury in quails and found that SY supplementation could alleviate DLM-induced cerebral toxicity by positively regulating the GPX4/TLR4 signaling pathway.

MOLECULAR NEUROBIOLOGY (2022)

添加到收藏夹

Article Cell Biology

Tetrahydrofolate Alleviates the Inhibitory Effect of Oxidative Stress on Neural Stem Cell Proliferation through PTEN/Akt/mTOR Pathway

Xuyang Zhang et al.

Summary: This study found that tetrahydrofolate (THF) can alleviate the inhibitory effect of oxidative stress on neural stem cell (NSC) proliferation through the PTEN/Akt/mTOR signaling pathway. This provides evidence for using THF to enhance the neuro-reparative capacity of NSC in the treatment of central nervous system diseases with the presence of oxidative stress.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

添加到收藏夹

Article Nutrition & Dietetics

Potential Therapeutic Effects of Tocotrienol-Rich Fraction (TRF) and Carotene Against Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways

Yifei Lu et al.

Summary: This study investigated the therapeutic effect of TRF and carotene on bleomycin-induced lung fibrosis and found that these substances could improve the condition by modulating different signaling pathways.

NUTRIENTS (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

Jincheng Wang et al.

Summary: This article discusses the progress made in understanding the complex interpretation of the cause of IPF, emphasizing the importance of the PI3K/AKT signaling pathway in IPF development, and explores the potential benefits of PI3K/AKT inhibitors in IPF treatment.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Article Environmental Sciences

The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis

Xue Yang et al.

Summary: As a synthetic pyrethroid pesticide, deltamethrin (DLM) is widely used in veterinary medicine and farming. DLM-induced oxidative stress causes harm to organisms. The purpose of this research was to study the impact and molecular mechanism of DLM on inflammation and apoptosis in quail cardiomyocytes through the Nrf2/HO-1 signaling pathway. The results showed that DLM induced dose-dependent cardiomyocyte injury by weakening antioxidant defense through down-regulating Nrf2 and HO-1. Furthermore, DLM stimulation induced apoptosis in quail heart and increased inflammation markers.

CHEMOSPHERE (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Protective Effect of Fasudil on Hydrogen Peroxide-Induced Oxidative Stress Injury of H9C2 Cardiomyocytes

Yu Zhang et al.

Summary: Diabetes is a common chronic disease worldwide, with complex pathogenesis often involving insufficient insulin secretion or reduced insulin sensitivity in patients. Additionally, diabetes is associated with various complications such as cardiovascular disease, retinopathy, among others.

DISEASE MARKERS (2021)

添加到收藏夹

Article Environmental Sciences

Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner

Fan Guohua et al.

Summary: This study investigated the potential roles of melatonin in PM2.5-induced lung injury and found that melatonin treatment alleviated lung pathological injury, edema, and inflammatory cell infiltration. Melatonin also inhibited ferroptosis and lipid peroxidation products in lung tissues and activated Nrf2 to protect against lung injury.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Review Environmental Sciences

Mechanisms of cardiovascular toxicity induced by PM2.5: a review

Tianyang Zhao et al.

Summary: Studies have shown that exposure to PM2.5 can affect cardiovascular diseases, with mechanisms including oxidative stress, increased vascular endothelial permeability, and more.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

添加到收藏夹

Article Immunology

Vasoactive intestinal peptide attenuates bleomycin-induced murine pulmonary fibrosis by inhibiting epithelial-mesenchymal transition: Restoring autophagy in alveolar epithelial cells

Jia-Xi Duan et al.

Summary: The study demonstrates that VIP attenuates bleomycin-induced pulmonary fibrosis in mice through restoring autophagy in alveolar epithelial cells, with anti-epithelial-mesenchymal transition (EMT) effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/ Drp1 pathway

Lei Hou et al.

Summary: The study demonstrates that MitoQ can alleviate LPS-induced AEC damage by preventing Nrf2/Drp1-mediated mitochondrial fission, AEC apoptosis, and barrier breakdown, exerting a protective effect in ALI.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Effects of Different Green Tea Extracts on Chronic Alcohol Induced-Fatty Liver Disease by Ameliorating Oxidative Stress and Inflammation in Mice

Bang-Yan Li et al.

Summary: Several green teas have been found to significantly reduce triacylglycerol levels and aminotransferase activities in mice, indicating hepatoprotective effects. These teas also decrease expression of cytochrome P450 2E1, levels of malondialdehyde and 4-hydroxynonenoic acid, and proinflammatory cytokines, suggesting they can alleviate oxidation damage and inflammation induced by chronic alcohol exposure. Additionally, some green teas can increase glutathione levels and certain phytochemical components may contribute to protective effects on AFLD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Respiratory symptoms, lung function, and fraction of exhaled nitric oxide before and after assignment in a desert environment-a cohort study

Johannes Saers et al.

Summary: The study found that exposure to desert storms in a desert environment led to a decrease in respiratory health, with a significant decrease in forced expiratory volume in 1 second (FEV1). This suggests that exposure to small particulate matter may contribute to the development of respiratory disease.

RESPIRATORY MEDICINE (2021)

添加到收藏夹

Article Nutrition & Dietetics

Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate

Ling Lin et al.

Summary: The study found that EGCG can regulate nutrient metabolism in rats by activating the AMPK and insulin pathways, while LTA cooperates with EGCG to promote glycogen metabolism and suppress the effects of EGCG on fatty acid and protein synthesis.

NUTRIENTS (2021)

添加到收藏夹

Article Environmental Sciences

Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM2.5 in mice

Mengmeng Xu et al.

Summary: Repeated intranasal instillation of PM2.5 induced lung inflammation, oxidative stress, mitochondrial damage, and pulmonary fibrosis in mice.

ENVIRONMENTAL TOXICOLOGY (2021)

添加到收藏夹

Review Cell Biology

Role of Natural Antioxidant Products in Colorectal Cancer Disease: A Focus on a Natural Compound Derived from Prunus spinosa, Trigno Ecotype

Maria Condello et al.

Summary: Colorectal cancer (CRC) is increasing in industrialized countries, emphasizing the need to find new compounds that are effective and have minimal adverse effects. Research suggests that natural compounds may have efficacy in CRC treatment, but careful selection of concentration is crucial to avoid paradoxical antioxidant and pro-oxidant effects.

CELLS (2021)

添加到收藏夹

Review Oncology

Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapy

Changxian Shen et al.

Summary: Immunotherapy has greatly improved clinical outcomes in many cancer patients, but only a small proportion benefit from it. The challenge now is to find biomarkers to predict response to this therapy and enhance patient sensitivity to it. Combining radiotherapy with immunotherapy shows potential in cancer treatment, with significant implications for patient care.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deglycosylated Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-β1 Signaling Pathway

Hao Ruan et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a life-threatening lung disease with no satisfactory treatment available. Abnormal activation of TGF-beta 1 plays a key role in the development of IPF. Deg-AZM exerts anti-fibrotic effects by inhibiting TGF-beta 1-induced myofibroblast activation and EMT.

MOLECULES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

Maxine J. Roberts et al.

Summary: Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Research has shown that sustained elevation of cAMP in the nucleus is necessary for efficient inhibition of PDGF-induced nuclear ERK and fibroblast proliferation in human lung fibroblasts.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Mechanisms of Endothelial-to-Mesenchymal Transition Induction by Extracellular Matrix Components in Pulmonary Fibrosis

O. A. Grigorieva et al.

Summary: The study found that fibrotic ECM can promote endothelial-to-mesenchymal transition process and increase the expression of transcription factors and production of fibrotic ECM components in endothelial cells. This may lead to the transition of endothelial cells into effector myofibroblasts.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response

Mian Wang et al.

Summary: EGCG from green tea can protect against LPS-induced acute lung injury by regulating the expression of PRKCA, reducing inflammatory response and lung damage.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

The cell cycle inhibitor P21 promotes the development of pulmonary fibrosis by suppressing lung alveolar regeneration

Xiaoxi Lv et al.

Acta Pharmaceutica Sinica B (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism

Guoyi Tang et al.

Summary: NAFLD is a series of liver disorders that have a huge impact on human health. Oxidative stress plays a key role in its development, and green tea and EGCG have been shown to have beneficial effects in preventing and managing NAFLD by protecting against oxidative stress and related metabolic dysfunction.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Genetics & Heredity

The critical role of epigenetic mechanism in PM2.5-induced cardiovascular diseases

Qinglin Sun et al.

Summary: Cardiovascular disease (CVD) has become the leading cause of death worldwide, closely associated with air pollution, particularly PM2.5. Recent studies suggest that PM2.5 exposure may induce or exacerbate CVD through epigenetic changes, involving DNA methylation, non-coding RNA, and more.

GENES AND ENVIRONMENT (2021)

添加到收藏夹

Article Plant Sciences

Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway

Yue Cui et al.

Summary: This study demonstrates that EGCG has a protective effect in pressure-overload cardiac hypertrophy by alleviating hypertrophy and fibrosis through inhibition of the Akt/mTOR pathway.

PHARMACEUTICAL BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation

Zhu-Lin Luo et al.

Summary: The study demonstrated that EGCG can significantly attenuate lung injury during acute pancreatitis by inhibiting NLRP3 inflammasome activation. The mechanism is mainly attributed to the elimination of mtROS and its oxidative product ox-mtDNA, thus providing protection against AP-associated lung injury.

FOOD & FUNCTION (2021)

添加到收藏夹

Article Cell Biology

Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD

Jing Wang et al.

MEDIATORS OF INFLAMMATION (2020)

添加到收藏夹

Article Plant Sciences

The epigallocatechin gallate derivative Y6 inhibits human hepatocellular carcinoma by inhibiting angiogenesis in MAPK/ERK1/2 and PI3K/AKT/HIF-1α/VEGF dependent pathways

Zhi-Hong Liao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

添加到收藏夹

Article Cell Biology

Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis

Lawei Yang et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Respiratory System

Long-term exposure to PM2.5 and Children's lung function: a dose-based association analysis

Sai Li et al.

JOURNAL OF THORACIC DISEASE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

Monira Pervin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Immunology

Immunological Pathogenesis of Membranous Nephropathy: Focus on PLA2R1 and Its Role

Wenbin Liu et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Nutrition & Dietetics

Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine

Ran Wei et al.

NUTRIENTS (2019)

添加到收藏夹

Article Environmental Sciences

Nickle(II) ions exacerbate bleomycin-induced pulmonary inflammation and fibrosis by activating the ROS/Akt signaling pathway

Lawei Yang et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2018)

添加到收藏夹

Article Environmental Sciences

NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter

Runxiao Zheng et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Epigallocatechin-3-gallate alleviates paraquat-induced acute lung injury and inhibits upregulation of toll-like receptors

Haitao Shen et al.

LIFE SCIENCES (2017)

添加到收藏夹

Review Plant Sciences

Green tea effects on cognition, mood and human brain function: A systematic review

Edele Mancini et al.

PHYTOMEDICINE (2017)

添加到收藏夹

Article Medicine, General & Internal

Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways

Zhen-Guo Ma et al.

EBIOMEDICINE (2017)

添加到收藏夹

Article Environmental Sciences

Association between satellite-based estimates of long-term PM2.5 exposure and coronary artery disease

Laura A. McGuinn et al.

ENVIRONMENTAL RESEARCH (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Environmental Particulate (PM2.5) Augments Stiffness-Induced Alveolar Epithelial Cell Mechanoactivation of Transforming Growth Factor Beta

Marilyn M. Dysart et al.

PLOS ONE (2014)

添加到收藏夹

Article Dermatology

Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway

Gyuman Park et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.