期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/4566949
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类别
资金
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Zhejiang Province of China
- [2021FZZX005-32]
- [LSY19H160004]
Chlorogenic acid (CGA) hinders the therapeutic effect of radiotherapy in hepatocellular carcinoma (HCC) cells by inhibiting radiation-induced apoptosis and DNA damage through scavenging excessive reactive oxygen species (ROS) and activating the NF-E2-related factor 2 (Nrf2) antioxidant system.
Radiotherapy produces excessive reactive oxygen species (ROS), which can lead to DNA damage and apoptosis in tumor cells, thereby killing malignant cells. Chlorogenic acid (CGA) is a well-known antioxidant in coffee due to its strong ability to remove ROS. However, the effect of CGA on radiotherapeutic efficacy remains unclear. In this study, we showed that CGA could hinder the therapeutic effect of radiotherapy by inhibiting radiation-induced apoptosis and DNA damage via scavenging excessive ROS and activating the NF-E2-related factor 2 (Nrf2) antioxidant system in hepatocellular carcinoma (HCC) cells and a murine model. The knockdown of Nrf2 reversed CGA-mediated radiation resistance in HCC cells. In conclusion, CGA might be a potential tumor-protective compound upon irradiation and reduce the efficacy of radiotherapy via ROS scavenging and Nrf2 activation.
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