期刊
ORGANIC LETTERS
卷 24, 期 33, 页码 6122-6127出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02021
关键词
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资金
- Science and Engineering Research Board (SERB) , New Delhi [CRG/2021/007153]
- DAE
- DST-INSPIRE
A Ni-catalyzed cascade reaction between 2-pyridone and alkynes has been achieved by tuning reaction conditions and incorporating a directing group. The use of sodium iodide as an additive plays a crucial role in the success of this transformation. The detection of a five-membered metallacycle intermediate through HRMS provides insights into the reaction mechanism.
A Ni-catalyzed C6 followed by C5 cascade C-H activation/[2 + 2 + 2] annulation of 2-pyridone with alkynes has been achieved. A change in the reaction pathway was achieved by tuning the reaction conditions and incorporating a directing group. A wide variety of substrates and alkynes are amenable to this transformation. The key to success for this transformation is the use of sodium iodide as an additive. More importantly, we detected the five-membered metallacycle intermediate through HRMS wherein iodide is ligated to the metal.
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