A Bi(OTf)3-Promoted Hydrosulfonylation of Alkenes with Sulfonyl Hydrazides: An Approach to Branched Sulfones

The Bi(OTf)(3)-promoted hydrosulfonylation of alkenes with sulfonyl hydrazides to produce branched sulfones is reported, in which various branched sulfones (>40 examples) have been prepared in moderate to good yields. The gram-scale reaction and synthesis of the experimental inhibitor precursor showed the potential application. A preliminary mechanistic study revealed that double-bond migration to form the alpha,beta-conjugated alkene is crucial for this transformation.

Automated summary

The Bi(OTf)(3)-promoted hydrosulfonylation of alkenes with sulfonyl hydrazides to produce branched sulfones is reported. Various branched sulfones were synthesized in moderate to good yields, highlighting the potential application of this reaction.