A Real-Time Strategy for Chiroptical Sensing and Enantiomeric Excess Determination of Primary Amines via an Acid-Base Reaction

Two achiral aromatic carboxylic acids that included the 1,8-naphthalimide group and an imidazolium cation were synthesized and exploited as chiroptical sensors. These compounds showed the real-time discrimination and enantiomeric excess determination of chiral amines and amino alcohols via an acid-base interaction, especially for UV-silent chiral compounds.

Automated summary

In this study, two novel achiral aromatic carboxylic acids were synthesized and used as chiroptical sensors for the real-time discrimination and enantiomeric excess determination of chiral amines and amino alcohols, especially for UV-silent chiral compounds.