期刊
ORGANIC LETTERS
卷 24, 期 28, 页码 5045-5050出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01815
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资金
- Ministry of Science and Technology (Taiwan) [MOST 110-2113-M-A49-008]
This study reports the isolation and stereochemical determination of the predominant native cholesteryl 6-O-phosphatidyl alpha- glucoside (CPG) from Helicobacter pylori. The authors used a combination of metabolic isolation and enzymatic degradation to obtain the native lactobacillic acid for stereochemical determination. The absolute stereochemistry of the acid was found to be 11R and 12S. Using this information, the authors achieved the total synthesis of predominant native CPG and other derivatives.
We report the isolation and stereochemical determination of the predominant native cholesteryl 6-O-phosphatidyl alpha- glucoside (CPG) from Helicobacter pylori via an integrated biological and chemical strategy. The strategy employed (i) the metabolic isolation of a CPG analogue and (ii) the enzymatic degradation of the analogue to obtain the native lactobacillic acid for the stereochemical determination. The absolute stereochemistry of the acid was found to be 11R and 12S. Using the new stereochemical data, we accomplished the total synthesis of predominant native CPG and other predominant alpha CG derivatives.
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