Visible-Light-Catalyzed Tandem Radical Addition/1,5-Hydrogen Atom Transfer/Cyclization of 2-Alkynylarylethers with Sulfonyl Chlorides

A novel visible-light-catalyzed tandem radical addition/ 1,5-hydrogen atom transfer/cyclization cascade of 2-alkynylarylethers with sulfonyl chlorides in 2-methyltetrahydrofuran was developed under photocatalyst-and additive-free conditions. This reaction relies on unique energy transfer and solvent-radical relay strategies to generate sulfonyl radicals for the preparation of a series of sulfonylfunctionalized dihydrobenzofurans in moderate to high yields catalyzed by visible light or solar radiation.

Automated summary

A novel visible-light-catalyzed tandem radical addition/1,5-hydrogen atom transfer/cyclization cascade reaction was developed for the synthesis of sulfonylfunctionalized dihydrobenzofurans. This reaction relies on unique energy transfer and solvent-radical relay strategies, enabling the generation of sulfonyl radicals under photocatalyst-and additive-free conditions.