期刊
ORGANIC LETTERS
卷 24, 期 25, 页码 4569-4574出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01654
关键词
-
资金
- National NSF of China [21878072, 21706058, 21725602, 21573065]
- NSF of Hunan Province [2020JJ2011]
- China Postdoctoral Science Foundation [2019M662774]
The cyclization-coupling reaction of 2-bromoaryl ketones and terminal alkynes is achieved for the first time by copper catalysis, producing polyfunctional naphthyl aryl ethers with broad substrate scope and good yields.
The cyclization-coupling reaction of 2-bromoaryl ketones and terminal alkynes is first realized by copper catalysis, which produces polyfunctional naphthyl aryl ethers in moderate to excellent yields with broad substrate scope and good functional group tolerance. This reaction proceeds via 6-endo-dig cyclization and C(sp(2))-O coupling using green H2O as the unique solvent and 5-bromopyrimidin-2-amine as the critical additive. Mechanistically, a unique Cu(III)-acetylide probably is the key intermediate, which allows exclusive 6-endo-dig selectivity.
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