Visible-Light-Induced, Palladium-Catalyzed Annulation of 1,3-Dienes to Construct Vinyl N-Heterocycles

Herein, a photoinduced palladium-catalyzed annulation of 1,3-dienes with bifunctional halognated alkylamines has been developed, offering a facile route to access a broad range of vinylpyrrolidines. The reactivity profile of this protocol was able to be readily manipulated to assemble vinylpyrrolidine and vinlysilaazacycle. Remarkably, the utility of this strategy was further illustrated in the construction of complex and biologically important molecules as well as the diversity-oriented transformations of the resulting product.

Automated summary

A photoinduced palladium-catalyzed annulation reaction has been developed for the synthesis of vinylpyrrolidines, which can be readily manipulated and diversified. This strategy demonstrates its utility in the construction of complex and biologically important molecules.