4.8 Article

Carboxylic Acid-Directed Manganese(I)-Catalyzed Regioselective Hydroarylation of Unactivated Alkenes

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ORGANIC LETTERS
卷 24, 期 33, 页码 6154-6158

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02309

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  1. National Natural Science Foundation of China [21871150, 22071118]
  2. Natural Science Foundation of Tianjin [21JCZDJC00350]
  3. Haihe Laboratory of Sustainable Chemical Transformations

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This study reported a regioselective hydroarylation reaction of unactivated alkenes with aryl boronic acids directed by carboxylic acid. The reaction was achieved by using a homogeneous manganese catalyst MnBr(CO)(5) in the presence of KOH and H2O in the m-xylene reaction medium. Both internal and terminal alkenes showed good reactivity in this transformation, and a variety of functional groups were tolerated.
A carboxylic acid-directed regioselective hydroarylation reaction of unactivated alkenes with aryl boronic acids was reported. This transformation was enabled by homogeneous manganese catalyst MnBr(CO)(5) in the presence of KOH and H2O in the m-xylene reaction medium. Both internal and terminal alkenes worked well in this transformation, and a series of functional groups were tolerated. This reaction not only provided an expeditious method to prepare gamma-aryl carboxylic acids from simple starting materials but also would inspire further studies in employing homogeneous manganese catalysis in organic synthesis.

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