期刊
ORGANIC LETTERS
卷 24, 期 30, 页码 5535-5540出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01957
关键词
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资金
- Hainan Province Key Science and Technology Project [ZDKJ202018]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2019BT02Y262]
- Fundamental Research & Applied Fundamental Research Major Project of Guangdong Province [2019B030302004]
- National Key Research and Development Program of China [2019YFC0312500]
- Rising Star Foundation of the South China Sea Institute of Oceanology [NHXX2019SW0101]
- National Natural Science Foundation of China [22037006]
- Open Program of Shenzhen Bay Laboratory [SZBL2021080601006]
Continuous mining of the Streptomyces olivaceus SCSIO T05 genome led to the discovery of new lipopeptides and the verification of their corresponding biosynthetic gene cluster.
Continuously mining the Streptomyces olivaceus SCSIO T05 genome leads to the identification of new lipopeptides (autucedines A-C), constituting members of the 10th skeleton isolated from this strain. The corresponding biosynthetic gene cluster (aut) was verified by heterogeneous expression, and another two analogues (autucedines D and E) were isolated from the heterogeneous expression strain. Gene inactivation experiments revealed that construction of the unique lipochainlinked dihydro-beta-alanine unit takes place prior to the NRPS assembly line.
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