Photoredox Metal-Free Allylic Defluorinative Silylation of α-Trifluoromethylstyrenes with Hydrosilanes

We report an efficient strategy that combines organic photoredox and hydrogen atom transfer to deliver gem-difluoroallylsilanes via defluorinative silylation of alpha-trifluoromethylstyrenes using hydrosilanes as silicon sources. This protocol provides an environmentally friendly approach for the preparation of structurally diverse gem-difluoroallylsilanes with excellent functional group compatibility and renders it suitable for late-stage modification of bioactive and complex molecules.

Automated summary

We have developed an efficient strategy that combines organic photoredox and hydrogen atom transfer to prepare gem-difluoroallylsilanes via defluorinative silylation of alpha-trifluoromethylstyrenes using hydrosilanes as silicon sources. This environmentally friendly approach allows for the preparation of structurally diverse gem-difluoroallylsilanes with excellent functional group compatibility, making it suitable for late-stage modification of bioactive and complex molecules.