Two Bioactive Compounds, Uniformides A and B, Isolated from a Culture of Nocardia uniformis IFM0856T in the Presence of Animal Cells

Two new peptides named uniformides A and B (1 and 2, respectively) were isolated from the cultured extracts of Nocardia uniformis IFM0856(T )in the presence of mouse macrophage-like cell line J774.1, in modified Czapek-Dox medium. These compounds were not produced in a culture containing only N. uniformis but in one that also included J774.1. Compounds 1 and 2 showed high cytotoxicity against J774.1 and suppressed the production of nitric oxide, IL-6, and IL-1 beta by inhibiting the NF-kappa B pathway.

Automated summary

Two new peptides named uniformides A and B (1 and 2) were isolated from the cultured extracts of Nocardia uniformis IFM0856(T) in the presence of mouse macrophage-like cell line J774.1, showing high cytotoxicity against J774.1 and inhibiting the production of nitric oxide, IL-6, and IL-1 beta through the suppression of the NF-kappa B pathway. These compounds were only produced in cultures containing J774.1.