Palladium Metallaphotoredox-Catalyzed 2-Arylation of Indole Derivatives

Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp(2))-H/C(sp(2))-H cross-coupling reactions to synthesize 2-arylindole derivatives by combining palladium catalysis and photocatalysis. This mild, dual-catalysis method showed good functional group tolerance and a wide substrate scope and could be used for late-stage functionalization of oligopeptides, drugs, and natural products.

Automated summary

Here, we report a two-step method for the construction of biaryl motifs by combining palladium catalysis and photocatalysis. This mild, dual-catalysis method showed good functional group tolerance and a wide substrate scope, making it suitable for the synthesis of 2-arylindole derivatives and late-stage functionalization of oligopeptides, drugs, and natural products.