期刊
ORGANIC LETTERS
卷 24, 期 31, 页码 5651-5656出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01901
关键词
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资金
- NISER, Department of Atomic Energy, Science and Engineering Research Board (SERB) , New Delhi [CRG/2021/007153]
- DAE
In this study, a Rh(III) catalyzed synthesis of alkynylated and bis-isocoumarin compounds from 1,3-dialkyne was reported. Exclusive one-pot formation of 3,3-bis-isocoumarin isomers was achieved, eliminating several other possibilities. This is the first example of transition metal catalyzed synthesis of alkynylated and bis-isocoumarin scaffolds, and the protocol is compatible with a wide range of functional groups.
We report here a Rh(III) catalyzed regio-and stereoselective synthesis of alkynylated and bis-isocoumarin from 1,3-dialkyne. Exclusive one-pot formation of 3,3-bis-isocoumarin isomers has been achieved by eliminating several other possibilities. This is the first example of transition metal catalyzed synthesis of alkynylated and bis-isocoumarin scaffolds. The protocol is compatible with a wide range of functional groups affording good to excellent yields. Several mechanistic investigations, including deuterium labeling experiments and kinetic isotope effect studies, have been carried out.
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