Synthesis of Benzofuran Derivates via a Gold-Catalyzed Claisen Rearrangement Cascade

A novel method toward a facile synthesis of diverse benzofuran derivates from easily obtained quinols and alkynyl esters has been reported. A gold-catalyzed intermolecular alkoxylation/Claisen rearrangement/condensation cascade was involved. The introduction of difluorodiphenylsilane as a water-trapping reagent in the reaction leads to a higher yield.

Automated summary

A novel method for synthesizing diverse benzofuran derivatives from easily obtained quinols and alkynyl esters has been reported. The method involves a gold-catalyzed intermolecular alkoxylation/Claisen rearrangement/condensation cascade. The introduction of difluorodiphenylsilane as a water-trapping reagent in the reaction leads to higher yield.