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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01918
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资金
- City University of Hong Kong [7005502, 7200579, 9610412, 9680283]
- Research Grants Council (RGC) of Hong Kong [21300219]
Characterization of a biosynthetic gene cluster in the fungus Aspergillus candidus CBS 102.13 led to the discovery of a new alkaloid, aspcandine (1). The unique molecular scaffold of aspcandine (1) is synthesized by the nonribosomal peptide synthetase-polyketide synthase hybrid AcdB, which incorporates 3-hydroxy-L-kynurenine as a building block. AcdB performs chain elongation using malonyl-CoA and releases the chain to form the tricyclic system of aspcandine (1).
Characterization of an orphan biosynthetic gene cluster found in the fungus Aspergillus candidus CBS 102.13 resulted in the discovery of a pyrrolobenzazepine alkaloid, aspcandine (1). The unique molecular scaffold of 1 is synthesized by the nonribosomal peptide synthetase-polyketide synthase hybrid AcdB, which unusually incorporates 3-hydroxy-L-kynurenine as a building block. AcdB subsequently performs one round of chain elongation using malonyl-CoA, which is followed by the chain release to furnish the tricyclic system of 1.
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