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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02330
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资金
- National Natural Science Foundation of China [22102072, 22171137]
- Natural Science Foundation of Jiangsu Province [BK20200765]
Efficient palladium-catalyzed synthesis of esters from available arenes has been achieved by regioselective thianthrenation to generate aryl-TT salts, which can couple with phenol formate and N-hydroxysuccinimide formate to form phenol esters and NHS esters, respectively. A wide range of functional esters can be prepared efficiently under this redox-neutral palladium-catalytic condition. The established platform and products show potential for late-stage functionalization and synthetic applications.
The efficient palladium-catalyzed synthesis of esters from readily available arenes has been developed. These C-H bond esterifications were achieved relying on the regioselective thianthrenation to generate the aryl-TT salts, which were treated as reactive electrophilic substrates to couple with phenol formate and N-hydroxysuccinimide (NHS) formate giving access to phenol esters and NHS esters, respectively, in the absence of carbon monoxide. A wide range of functional esters could be prepared with high efficiency under this redox-neutral palladium-catalytic condition. Late-stage functionalization and investigations of synthetic applications demonstrated the potential application of the established platform and these products.
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