期刊
ORGANIC LETTERS
卷 24, 期 23, 页码 4229-4233出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01545
关键词
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资金
- NSFC [21872028]
- Natural Science Foundation of Fujian Province [2020J01149]
- Fujian Province University Fund for New Century Excellent Talents
- STU Scientific Research Foundation for Talents [NTF20022]
An approach to electrochemical oxygenation of indoles leading to isatins was developed by merging with a complementary cathode oxygen reduction reaction. The green protocol features the use of molecular oxygen as the sole oxidant and gram-scale preparation without an electron transfer mediator. Mechanistic studies suggest a radical process with both oxygen atoms in the isatins most likely originating from molecular oxygen. A detailed mechanism of the reaction was elucidated using density functional theory calculations.
An approach to electrochemical oxygenation of indoles leading to isatins was developed by merging with a complementary cathode oxygen reduction reaction. The features of this green protocol include the use of molecular oxygen as the sole oxidant, it being free of an electron transfer mediator, and gram-scale preparation. Mechanistic studies suggested a radical process, and the two oxygen atoms in the isatins were both most likely from molecular oxygen. A detailed mechanism of the reaction utilizing density functional theory calculations was elucidated.
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