期刊
OPTICS AND LASERS IN ENGINEERING
卷 155, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.optlaseng.2022.107066
关键词
Structured illumination microscopy; Super-resolution; Deep learning
类别
资金
- National Natural Science Foundation of China (NSFC) [62075140, 61805086, 61727814, 61875059, 62175041]
- Science, Technology and Innovation Commission of Shen-zhen Municipality [20201026165007001]
- Guangdong Basic and Applied Basic Research Foundation [2021A1515110664]
- Start-Up Fund-ing of Guangdong Polytechnic Normal University [2022SDKYA008]
This research presents a deep learning-based method for structured illumination microscopy (SIM) that can reconstruct super-resolution (SR) images using only one frame of structured illumination image. Generative adversative networks (GANs) and deformation of U-Net (DU-Net) are utilized for the task. Experimental and simulation results demonstrate the ability to reconstruct SR images from a single frame of structured illumination image, significantly reducing phototoxicity and photobleaching.
We report a deep learning-based structured illumination microscopy (SIM) method, which can reconstruct a super-resolution (SR) image using only one frame structured illumination image. Generative adversative networks (GANs) and deformation of U-Net (DU-Net) are employed to perform the task. GANs are trained to generate other structured illumination images by feeding a single structured illumination image, and DU-Net is trained to reconstruct the super-resolution image. The results of experiments and simulations demonstrate that the SR image could be reconstructed from one frame structured illumination image. Importantly, it can greatly reduce phototoxicity and photobleaching.
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