期刊
ONCOLOGIST
卷 27, 期 10, 页码 864-873出版社
OXFORD UNIV PRESS
DOI: 10.1093/oncolo/oyac137
关键词
brentuximab vedotin; peripheral T-cell lymphoma; cutaneous T-cell lymphoma; immunohistochemistry; non-Hodgkin lymphoma
类别
资金
- Seagen, Inc. [SGN35-IST-002]
- Haas Family Foundation
- Millennium Pharmaceuticals Inc
- Seagen Inc.
- Seagen Inc. [SGN35-IST-r001, SGN35-012, SGN35-IST-030]
- National Cancer Institute (NCI) MD Anderson Cancer Center Core Grant [CA16672-22]
- NCI [R21-CA74117]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant [K24 CA 86815]
- Cutaneous T-Cell Lymphoma (CTCL) Patient Education and Research Fund
- Sherry L. Anderson Fund for CTCL Research
This article examines the relationship between CD30 expression level and clinical response to brentuximab vedotin. The analysis showed that CD30 expression alone cannot predict the clinical benefit of brentuximab vedotin.
The safety and efficacy of brentuximab vedotin, an antibody-drug conjugate directed to the CD30 antigen, has been assessed in several trials in patients with lymphoma. This article examines the relationship between CD30 expression level and clinical response to brentuximab vedotin. Background The safety and efficacy of brentuximab vedotin (BV), an antibody-drug conjugate directed to the CD30 antigen, has been assessed in several trials in patients with peripheral T-cell lymphoma (PTCL), cutaneous T-cell lymphoma (CTCL), or B-cell non-Hodgkin lymphoma (NHL). The objective of this research was to examine the relationship between CD30 expression level and clinical response to BV. Patients and Methods We analyzed response in patients treated with BV monotherapy in 5 prospective clinical studies in relapsed or refractory PTCL, CTCL, or B-cell NHL. CD30 expression was assessed by immunohistochemistry (IHC) using the Ber H2 antibody for 275 patients. Results Across all 5 studies, 140 (50.9%) patients had tumors with CD30 expression <10%, including 60 (21.8%) with undetectable CD30 by IHC. No significant differences were observed for any study in overall response rates between patients with CD30 expression >= 10% or Conclusions In this analysis of studies across a range of CD30-expressing lymphomas, CD30 expression alone, as measured by standard IHC, does not predict clinical benefit from BV, making the determination of a threshold level of expression uncertain.
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