4.8 Article

ROR1-targeting switchable CAR-T cells for cancer therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Immunology

Safety switches for adoptive cell therapy

Ali Can Sahillioglu et al.

Summary: The development of genetic safety switches to control the activity of T cells in vivo has become an active research field. These switches can reversibly control cell products through the supply or removal of small molecules, protein-based regulators, or physical stimuli. Various mechanistic classes of genetic safety switches are discussed in this review.

CURRENT OPINION IN IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

Louai Labanieh et al.

Summary: SNIP CARs are a protease-based CAR platform that can regulate CAR activity using an FDA-approved small molecule. SNIP CAR-T cells exhibit higher potency and show reduced T cell exhaustion and enhanced stemness compared to constitutive CAR-T cells in various models. In a ROR1-based CAR lethality model, toxicity can be reversed by stopping the drug, and tumor eradication without toxicity can be achieved by reducing the drug dosage. SNIP CARs provide a solution to the safety and efficacy barriers currently limiting the use of CAR-T cells in treating solid tumors by enabling remote tuning of CAR activity.
Article Oncology

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

Shivani Srivastava et al.

Summary: CAR-T therapy shows limited efficacy in lung adenocarcinoma, but combining oxaliplatin, cyclophosphamide, and anti-PD-L1 can improve CAR-T cell infiltration into tumors and enhance efficacy.

CANCER CELL (2021)

Review Oncology

Chimeric antigen receptor T cell therapy in oncology-Pipeline at a glance: Analysis of the ClinicalTrials.gov database

E. Moreno-Cortes et al.

Summary: The rapid growth of CAR T-cell therapy in clinical trials, particularly in the field of hematologic malignancies, is evident. Apart from China and the USA, other countries are also starting to participate in research in this area, with the expectation of more CAR T-cell therapy clinical trials in the future.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Review Cell Biology

The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention

Kerstin Menck et al.

Summary: The WNT pathway, especially through ROR signaling, plays a crucial role in tumor development. Overexpression of ROR is associated with tumor progression, highlighting its significance in cancer therapy.
Article Oncology

Shaping Functional Avidity of CAR T Cells: Affinity, Avidity, and Antigen Density That Regulate Response

Raanan Greenman et al.

Summary: This study investigates the functional significance of the biophysical properties of CAR binding by constructing a series of CARs targeting the melanoma tumor-associated antigen Tyr/HLA-A2. The research demonstrates nonmonotonic behaviors of affinity and antigen density, as well as an interrelation between avidity and antigen density, in CAR T cell function.

MOLECULAR CANCER THERAPEUTICS (2021)

Review Pharmacology & Pharmacy

CAR-T cells: Early successes in blood cancer and challenges in solid tumors

Hassan Dana et al.

Summary: New approaches in cancer immunotherapy, such as checkpoint inhibitors for solid tumors and CAR-T cell therapy for hematologic malignancies, have shown promising results. While CAR-T products have demonstrated powerful effects against B cell cancers, challenges exist in using them for solid tumors.

ACTA PHARMACEUTICA SINICA B (2021)

Review Oncology

Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies

Yuming Zhao et al.

Summary: ROR1, a receptor tyrosine kinase, is crucial in embryogenesis and overexpressed in malignant tumors, with potential as a target for cancer therapy. Antibody-based immunotherapies show promising outcomes, while small molecule inhibitors are underappreciated. Further research is needed to understand ROR1's tyrosine kinase function and develop effective therapeutic strategies.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

Review Biotechnology & Applied Microbiology

'Off-the-shelf' allogeneic CAR T cells: development and challenges

S. Depil et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Chemistry, Multidisciplinary

Chemically Programmable and Switchable CAR-T Therapy

Junpeng Qi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Biochemistry & Molecular Biology

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications

Rebecca S. Goydel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor

Nicholas G. Minutolo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Multidisciplinary Sciences

Chimeric antigen receptor signaling: Functional consequences and design implications

S. E. Lindner et al.

SCIENCE ADVANCES (2020)

Review Oncology

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Mihe Hong et al.

CANCER CELL (2020)

Article Medicine, General & Internal

CAR-T design: Elements and their synergistic function

Jayapriya Jayaraman et al.

EBIOMEDICINE (2020)

Review Biochemistry & Molecular Biology

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Mohamed-Reda Benmebarek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

The Emergence of Universal Immune Receptor T Cell Therapy for Cancer

Nicholas G. Minutolo et al.

FRONTIERS IN ONCOLOGY (2019)

Review Pharmacology & Pharmacy

Therapeutic approaches for targeting receptor tyrosine kinase like orphan receptor-1 in cancer cells

Amin Kamrani et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Article Biotechnology & Applied Microbiology

Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform

Julian Rydzek et al.

MOLECULAR THERAPY (2019)

Review Hematology

An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer

Steven Feins et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

Article Biochemistry & Molecular Biology

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Jang Hwan Cho et al.

Review Oncology

The expansion of targetable biomarkers for CAR T cell therapy

Michelle H. Townsend et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Review Multidisciplinary Sciences

CAR T cell immunotherapy for human cancer

Carl H. June et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Sophie Viaud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Oncology

Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues

Ashwini Balakrishnan et al.

CLINICAL CANCER RESEARCH (2017)

Article Biochemistry & Molecular Biology

Mining Naive Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility

Haiyong Peng et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Article Chemistry, Multidisciplinary

Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer

Yu Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Multidisciplinary Sciences

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

David T. Rodgers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

Designing chimeric antigen receptors to effectively and safely target tumors

Michael C. Jensen et al.

CURRENT OPINION IN IMMUNOLOGY (2015)

Review Pharmacology & Pharmacy

Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy

Mahdi Shabani et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

Article Multidisciplinary Sciences

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

Chia-Yung Wu et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Economical analysis of saturation mutagenesis experiments

Carlos G. Acevedo-Rocha et al.

SCIENTIFIC REPORTS (2015)

Article Oncology

Safety of Targeting ROR1 in Primates with Chimeric Antigen Receptor-Modified T Cells

Carolina Berger et al.

CANCER IMMUNOLOGY RESEARCH (2015)

Review Oncology

The receptor tyrosine kinase ROR1-An oncofetal antigen for targeted cancer therapy

Mohammad Hojjat-Farsangi et al.

SEMINARS IN CANCER BIOLOGY (2014)

Article Pharmacology & Pharmacy

How to calculate sample size in animal studies?

Jaykaran Charan et al.

JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS (2013)

Article Immunology

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

Daphne A. Schmid et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Design of HIV vectors for efficient gene delivery into human hematopoietic cells

PY Yam et al.

MOLECULAR THERAPY (2002)