期刊
ONCOGENE
卷 41, 期 33, 页码 3979-3990出版社
SPRINGERNATURE
DOI: 10.1038/s41388-022-02386-8
关键词
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资金
- National Natural Science Foundation of China [81902576, 81725016, 81872094, 82002684]
- Natural Science Foundation of Guangdong Province, China [2017B020227004, 2017A030313538]
- China Postdoctoral Science Foundation [2020M683082]
The circular RNA circME1 enhances the malignant phenotype of ccRCC by upregulating the expression of its parental gene ME1 and plays a role in the development of sunitinib resistance.
Circular RNAs (circRNAs) play critical roles in clear cell renal cell carcinoma (ccRCC). However, their involvement in sunitinib resistance remains largely unknown. Herein, we identified a novel circRNA, named circME1, which contributes to sunitinib resistance development in ccRCC. CircME1 also promoted proliferation, migration, and invasion of ccRCC cells. Further mechanism analysis showed that circME1 interacted with U1 snRNP at the promoter of its parental gene ME1, thereby upregulating the expression of ME1, enhancing aerobic glycolysis of ccRCC, and promoting its malignant phenotype. Furthermore, ME1 specific inhibitor could effectively repress the oncogenic functions of circME1. Taken together, our study demonstrates that the circME1/ME1 pathway is involved in ccRCC progression and sunitinib resistance development, which may be exploited for anticancer therapy.
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