期刊
JOURNAL OF DAIRY SCIENCE
卷 99, 期 6, 页码 4693-4698出版社
ELSEVIER SCIENCE INC
DOI: 10.3168/jds.2015-10543
关键词
Escherichia coli; mastitis; autoinducer 2 (AI-2) quorum sensing; extended spectrum beta-lactamase
资金
- Project of Anhui Province Key Discipline of Biology (Anhui, China) [2014TSTD003]
- Talent Project of Anhui Agricultural University (Anhui, China) [YJ2013-6]
Extended spectrum beta-lactamase (ESBL)-positive Escherichia coli is a major etiological organism responsible for bovine mastitis. The autoinducer 2 (AI-2) quorum sensing system is widely present in many species of gram-negative and gram-positive bacteria and has been proposed to be involved in interspecies communication. In E. coli model strains, the functional mechanisms of AI-2 have been well studied; however, in clinical antibiotic-resistant E. coli strains, whether AI-2 affects the expression of antibiotic resistance genes has not been reported. In this study, we report that exogenous AI-2 increased the antibiotic resistance of a clinical E. coli strain isolated from a dairy cow with mastitis by upregulating the expression of TEM-type enzyme in an LsrR (LuxS regulated repressor)-dependent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据